source: Gilgamesh vs Fairy Tail

DESPISE, CONTEMN, SCORN, DISDAIN mean to regard as unworthy of one's notice or consideration.

DESPISE may suggest an emotional response ranging from strong dislike to loathing.

e.g. despises cowards

CONTEMN implies a vehement condemnation of a person or thing as low, vile, feeble, or ignominious.

e.g. contemns the image of women promoted by advertisers

SCORN implies a ready or indignant contempt.

e.g. scorns the very thought of retirement

DISDAIN implies an arrogant or supercilious aversion to what is regarded as unworthy.

e.g. disdained popular music

the feeling that someone or something is unworthy of one's consideration or respect; contempt:

«…に対する» (優越感からくる)軽蔑, 侮辱, 高慢(な態度) «for»

e.g. her upper lip curled in disdain

e.g. an aristocratic disdain for manual labor.

verb with object

consider to be unworthy of one's consideration:

〈人が〉〈人･物など〉を軽蔑する, 侮辱する, 見下す

e.g. gamblers disdain four-horse races.

refuse or reject (something) out of feelings of pride or superiority:

｟かたく｠ ; 〖～ to do/｟まれ｠ doing〗 〈人が〉…することを恥とする, …するに値しないと思う

e.g. she remained standing, pointedly disdaining his invitation to sit down

e.g. with infinitive : he disdained to discuss the matter further.

Middle English: from Old French desdeign (noun), desdeignier (verb), based on Latin dedignari, from de- (expressing reversal) + dignari ‘consider worthy’ (from dignus ‘worthy’).