source: [この素晴らしい世界に祝福を!の魔法で大爆発が起きるGIF画像｜無料GIF画像検索 GIFMAGAZINE 864336]

the action or process of causing so much damage to something that it no longer exists or cannot be repaired:

破壊(する, されること), 破壊行為(↔ construction); 破滅状態

e.g. the destruction of the library in Alexandria

e.g. the avalanche left a trail of destruction.

the action or process of killing or being killed:

e.g. the wanton destruction of human life.

in singular a cause of someone's ruin:

〖A's ～〗 A〈人〉の破滅の原因

e.g. gambling was his destruction.

Middle English: from Latin destructio(n-), from the verb destruere (see destroy).