source: I think the title "Made in Abyss" is pretty damn poetic. - Forums - MyAnimeList.net

DISTRESS, SUFFERING, MISERY, AGONY mean the state of being in great trouble.

DISTRESS implies an external and usually temporary cause of great physical or mental strain and stress.

e.g. the hurricane put everyone in great distress

SUFFERING implies conscious endurance of pain or distress.

e.g. the suffering of famine victims

MISERY stresses the unhappiness attending especially sickness, poverty, or loss.

e.g. the homeless live with misery every day

AGONY suggests pain too intense to be borne.

e.g. in agony over the death of their child

noun (plural agonies)

extreme physical or mental suffering:

(肉体的な)激しい痛み, 苦痛; (精神的な)苦痛, 苦悩(torment)

e.g. he crashed to the ground in agony.

the final stages of a difficult or painful death:

〖時に-nies〗死［断末魔］の苦しみ

e.g. his last agony

e.g. the death agony.

late Middle English (originally denoting mental anguish alone): via Old French and late Latin from Greek agōnia, from agōn ‘contest’. The sense of physical suffering dates from the early 17th century.