vex + -ation

source: 少女終末旅行 叩かれるチト｜NBHmaru｜GIFMAGAZINE

the state of being annoyed, frustrated, or worried:

｟かたく｠ いらだたせる［いらだつ］こと, 苦しめる［苦しむ］こと; いらだたしさ

e.g. Jenny bit her lip in vexation.

something that causes annoyance, frustration, or worry:

｟かたく/やや古｠ ; 〖しばしば～s〗 いらいらさせるもの; 悩み［苦しみ］の種

e.g. the cares and vexations of life.

late Middle English: from Old French, or from Latin vexatio(n-), from vexare (see vex).